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Treating, curing and preventing disease - OCR Gateway The immune system in defence against disease

Pathogens are everywhere. The body has evolved defences that act to prevent pathogens entering it. If a pathogen does enter the body then the immune system helps to fight it off.

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The immune system of the human body in defence against disease

An illustrated scene of a phatocyte's cell membrane surrounding a pathogen
Figure caption,
Phagocyte engulfing a bacterial cell

If manage to pass the non-specific first line of defence then they will cause an infection. However, the body has a second line of defence to stop or minimise this infection. This is called the . As a part of this there are two types of white blood cell called and .

Phagocytes

Phagocytes are white blood cells that are attracted to pathogens and attach to them. Once they have attached to the pathogen, the phagocyte's cell membrane surrounds the pathogen and engulfs it. This means the pathogen is taken inside of the phagocyte.

Enzymes found inside the phagocyte break down the pathogen and destroy it. Phagocytes do this to all pathogens that they encounter, so they are called 'non-specific'.

Lymphocytes

A scientific impression of a lymphocyte white blood cell

Lymphocytes are another type of white blood cell. They recognise proteins on the surface of pathogens called . Lymphocytes detect that these pathogen antigens are foreign and not naturally occurring within the body, leading the lymphocyte to produce . This process can take a few days, during which time a person may feel ill. The antibodies are released into the blood and bind to pathogens. This causes the pathogens to stick together, restricting their movement around the body and making it easier for phagocytes to engulf and then destroy them.

Diagram showing how antibodies attach themselves to antigens
Diagram showing how antibodies cause pathogens to stick together
Figure caption,
Antibodies released by lymphocytes can attach to pathogens which leads to the destruction of the pathogen

Some pathogens produce which make you feel ill. Lymphocytes can also produce to neutralise these toxins. This means that the toxins cannot bind to body cells and cause damage. Both the antibodies and antitoxins are highly specific to the antigen or toxin that is made by the pathogen, therefore the lymphocytes that produce them are called 'specific'.