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Blood glucose levels and obesityInsulin

Pancreatic receptors are involved in negative feedback control of blood glucose through insulin, glucagon and adrenaline. People with type 1 diabetes are unable to produce insulin. In type 2 diabetes, individuals produce insulin but their cells are less sensitive to it. Obesity is a major risk factor for cardiovascular disease and type 2 diabetes.

Part of Human BiologyPhysiology and Health

Insulin

is a hormone produced by the . It regulates glucose concentrations in the blood.

If the blood glucose concentration is too high, the pancreas produces insulin. This causes glucose to move from the blood into the cells, where the excess glucose is stored:

  • some is stored as body fat
  • liver and muscle cells convert excess glucose to for storage and use at a later date

Action of insulin

Low glucoseHigh glucose
Effect on pancreasInsulin not secreted into the bloodInsulin secreted into the blood
Effect on liverDoes not convert glucose into glycogenConverts glucose into glycogen
Effect on blood glucose levelIncreasesDecreases
Effect on pancreas
Low glucoseInsulin not secreted into the blood
High glucoseInsulin secreted into the blood
Effect on liver
Low glucoseDoes not convert glucose into glycogen
High glucoseConverts glucose into glycogen
Effect on blood glucose level
Low glucoseIncreases
High glucoseDecreases

The diagram illustrates how insulin works in the body:

Too much glucose. Pancreas produces insulin, body cells  absorb glucose, blood glucose reduced. Normal levels, insulin not produced by pancreas, less glucose absorbed, blood glucose remains same.