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What are the causes of disease? - OCR 21st CenturyFighting back

Diseases are abnormal conditions that affect an organism鈥檚 body, organs, tissues or cells. Some are caused by pathogens, and organisms have defences to them.

Part of Biology (Single Science)Keeping healthy

Fighting back

Human immunity

The immune system defends the body against disease.

If pass the non-specific first line of defence they will cause an infection. However, the body has a second line of defence to stop or minimise this infection. This is called the .

All cells have proteins called antigens on their surfaces. All cells have molecules that can trigger an immune response, called . Antigens can be used for recognition. White blood cells are able to attack pathogens because they have antigens that are recognised as 'non-self'. Antigens on body cells are recognised as 'self'.

White blood cells

One type of white blood cell is attracted to pathogens and bind to them. Then they ingest and digest the pathogen.

As they do this to all pathogens that they encounter, we call them 'non-specific'.

White blood cell engulfing a bacterial cell
Image caption,
White blood cell engulfing a bacterial cell

Antibodies

Another type of white blood cell makes antibodies. These white blood cells can distinguish between 'self' and 'non-self (foreign) antigens. This means that they can detect if proteins on the surface of pathogens are foreign or do not naturally occur within the body and they then produce .

Each white blood cell makes only one type of antibody. Each type of antibody attaches to only one specific antigen. The organism must make different antibodies for each type of pathogen. The antibodies cause pathogens to stick together and make it easier for white blood cells to engulf them.

The immune response

There are some diseases you can only catch once. This is because your body has developed immunity to them. The reason this happens is that memory cells stay in your blood. These are white blood cells from your first immune response. They can remain for many years, and mean that you have a faster immune response if you are exposed to the pathogen again because antibodies can be made as soon as the pathogen appears.

Plant defence responses

Just like animals, plants are constantly defending themselves from attack from . Again like us, plants have physical and chemical defences which stop pathogens from infecting them and causing disease.

Physical defences

Many plants are covered with a thick bark. This is an external layer of dead cells which forms a physical barrier against infection. In this way it is very much like our skin. Beyond bark, each plant cell has a cell wall which acts as another barrier against infection. Leaves are covered with a waxy which also stops their cells from becoming infected.

Chemical defences

Some plants, such as mint and witch hazel, produce chemicals. These limit the spread of and other pathogens that were not stopped by physical defences. We now use these chemical defences in antiseptics for humans.

Other defences

Farmers can now crop plants to be resistant to infections.