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Non-specific body defencesThe immune system

The immune system defends humans from pathogens. Physical and chemical barriers prevent infection. White blood cells attack pathogens. Immunisations usually involve injecting inactive pathogens.

Part of Human BiologyNeurobiology and immunology

The immune system

The body has a second line of defence to stop or minimise infection. This is called the and mainly consists of two types of white blood cells:

Phagocytes

Coloured scanning electron micrograph (SEM) of a macrophage white blood cell engulfing a tuberculosis (Mycobacterium tuberculosis) bacterium (orange).
Image caption,
Phagocyte engulfing a bacterial cell

About 70 per cent of the white blood cells are phagocytes. They are part of the body鈥檚 immune system, but they do not produce antibodies. Instead, they ingest and destroy pathogens such as bacteria.

Phagocytes recognise and destroy them by the process of . Phagocytosis involves the engulfing of pathogens and their destruction by digestive enzymes contained in lysosomes.

The phagocyte's membrane surrounds the pathogen and engulfs it in a . Enzymes found inside the cell then break down the pathogen in order to destroy it. As phagocytes do this to all pathogens that they encounter, they are called non-specific.

During the immune response phagocytes also release cytokines (proteins that acts as a signalling molecules) which attracts more phagocytes to the site of infection.

Phagocytes pass through blood vessel walls into the surrounding tissue