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The action in The Curious Incident of the Dog in the Night-Time revolves around the protagonist Christopher Boone. Initially, the audience watches him interact with Mrs Shears (the owner of Wellington the dog), his teacher, Siobhan, and his father, Ed. Once Christopher begins his investigation into the murder of Wellington he comes into contact with Mrs Alexander, his elderly neighbour, and as his story moves to London he makes contact with Judy, his mother whom he thought was dead, and her boyfriend, Roger who was married to Mrs Shears.

Christopher meets a number of minor characters along the way including 'Man with Socks', 'Punk Girl', a number of policemen, Reverend Peters and his head teacher, Mrs Gascoyne.

Main characters

• Christopher Boone
• Ed Boone
• Judy Boone

Secondary characters

• Siobhan
• Roger Shears
• Mrs Alexander

Minor characters

• Mrs Shears
• Reverend Peters
• Mrs Gascoyne