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Maintaining nitrogen balance in the body – Higher

The digestion of proteins from the diet results in excess amino acids, which need to be excreted safely. In the liver deamination takes place to form ammonia. Ammonia is and so it is immediately converted to for safe excretion.

Diagram of the human digestive system

Once we have eaten our food, it is then digested by the body. The of is broken down by enzymes into in the stomach and small intestine.

Protease molecules breaking down proteins into amino acids

When excessive amounts of protein are eaten, the excess amino acids produced from digesting proteins are transported to the liver from the small intestine. The liver controls the amino acid concentration in the body, as excess amino acids which need to be safely. The body is unable to store proteins or amino acids.

In the liver, ammonia is formed by the deamination of amino acids. It is highly toxic and cannot be allowed to accumulate in the body. Excess ammonia is converted to urea. Urea and water are released from the liver cells in to the bloodstream and transported to the kidneys where the blood is filtered and the urea is passed out of the body in the urine.