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DNA structure

The structure of DNA

James Watson and Francis Crick worked out the structure of in 1953. By using data from other scientists (Rosalind Franklin and Maurice Wilkins) they were able to build a model of DNA. The X-ray crystallography data they used showed that DNA consists of two strands coiled into a .

Image gallerySkip image gallerySlide 1 of 2, The famous X-ray diffraction photograph of DNA taken by Rosalind Franklin, known as photograph 51., The famous X-ray diffraction photograph of DNA taken by Rosalind Franklin, known as photograph 51

DNA is a polymer made from four different . Each nucleotide monomer consists of a deoxyribose sugar and phosphate group with one of the four different attached to the sugar. The nucleotides are arranged in a repeating fashion to create DNA.

A nucleotide consisting of a deoxyribose sugar, phosphate and base
Figure caption,
A nucleotide
A visual to describe the base pairs in DNA.

Base pairs - Higher

Each rung of the 'ladder' is made of chemicals called bases. Note that these are different to bases in relation to acids and alkalis in chemistry.

There are four different bases in DNA:

  • thymine, T
  • adenine, A
  • guanine, G
  • cytosine, C

They always pair up in a particular way, called base pairing:

  • thymine pairs with adenine (T-A or A-T)
  • guanine pairs with cytosine (G-C or C-G)

There are weak bonds connecting the pairs of bases between the two strands of the DNA.

DNA strand showing bases pairs: TA, GC, AT repeated randomly.
Figure caption,
Base pairs on a section of DNA

The genetic code - Higher

A sequence of three bases (a triplet) is the code for a particular amino acid. This is why it is sometimes called the . The four bases - A, T, C and G - can be arranged in 64 different ways. As there are only 20 possible amino acids, there is more than one code for each amino acid. There are also codes which mean 'start and 'stop'. The order of the bases controls the order in which amino acids are assembled to produce a particular protein.