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Primary and secondary infection

Vaccination acts as a that results in a more rapid immune response to a secondary infection.

During primary response, there is an antibody concentration rise over 7 days, dropping to just above zero by 20 days. During secondary phase a sharp rise levels off at a peak after 30 days.

During the primary infection the antibodies slowly increase, peak at around ten days and then gradually decrease. This primary infection results in the production of memory cells that remain in the bloodstream.

A second exposure to the same pathogen causes the white blood cells to respond quickly in order to produce lots of the relevant antibodies, which prevents infection.

The antibodies are produced so quickly by the that the pathogen is killed off before it can make the person ill. This is called being immune to a disease or having .

Adjuvants

Adjuvants may be added to a vaccine to boost the immune response. They help to produce more antibodies and longer-lasting immunity and, as a result, smaller amounts of antigens are needed.

Aluminum hydroxide and paraffin oil are two of the most common adjuvants.